Matrix Rigidity Induces Osteolytic Gene Expression of Metastatic Breast Cancer Cells
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چکیده
منابع مشابه
Matrix Rigidity Induces Osteolytic Gene Expression of Metastatic Breast Cancer Cells
Nearly 70% of breast cancer patients with advanced disease will develop bone metastases. Once established in bone, tumor cells produce factors that cause changes in normal bone remodeling, such as parathyroid hormone-related protein (PTHrP). While enhanced expression of PTHrP is known to stimulate osteoclasts to resorb bone, the environmental factors driving tumor cells to express PTHrP in the ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0015451